Preclinical Safety Testing Program for Pharma/Biotech

Toxikon's "Preclinical Safety Testing Program for Pharma/Biotech" includes a wide range of pharmacokinetic, acute toxicity, repeat dose toxicity, genotoxicity and developmental and reproductive toxicology studies. (See list below).

For more information on the studies listed below, click here to download a PDF of Toxikon's sample study designs.

For more specifics, or for information on Toxikon's Custom capabilities, click here or fill out the form to the right.

 Pharmacokinetic Studies 

Single Dose PK Study in Sprague Dawley Rats     

Single Dose PK Study in Non-Naïve Beagle Dogs—Parallel Session            

Single Dose PK Study in Non-Naïve Beagle Dogs —4 Crossover Sessions

Repeat Dose PK Study in Non-Naïve Beagle Dogs  

Acute Toxicity—Sample Designs             

Single-Dose Toxicity Study in Sprague Dawley Rats          

Single-Dose Toxicity Study in Beagle Dogs            

MTD Determination with Repeat Dose Range-Finding in Sprague Dawley Rats    

MTD Determination with Repeat Dose Range-Finding in Beagle Dogs 

Repeat Dose Toxicity Studies—GLP   

14-Day Repeat Dose Toxicity Study in Rats           

14-Day Repeat Dose Toxicity Study in Beagle Dogs           

28-Day Repeat Dose Toxicity Study in Rats           

28-Day Repeat Dose Toxicity Study in Beagle Dogs           

90-Day Repeat Dose Toxicity Study in Rats           

10-Day Repeat Dose Toxicity Study in Beagle Dogs      

Genotoxicity Studies     

Ames Reverse mutation assay in S. typhimurium and E.coli                         

Chromosomal Aberration Assay with CHO cells                 

Chromosomal Aberration Assay with Human Lymphocytes                         

Rodent Bone Marrow Micronucleus Test                             

Dose-Verification Study       

Developmental & Reproductive Toxicology         

Embryo Fetal Development Study in Rats—Dose Range Finding

Embryo Fetal Development Study in Rats—Definitive    

Embryo Fetal Development Study in Rabbits—Dose Range Finding          

Embryo Fetal Development Study in Rabbits—Definitive              

Fertility Study in Rats     

Pre and Post Natal Development Study in Rats 

 

To request medical device development tests, click the Devices icon.

  

 

                    

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